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Liposome is a very wide range of pharmaceutical carrier materials, which can form a unique phospholipid bilayer directional arrangement structure. It can not only encapsulate hydrophilic drugs in the inner water phase, but also encapsulate lipophilic drugs in the phospholipid bilayer. After intravenous injection, lipid can effectively delay drug release and improve bioavailability. In addition, liposomes have good compatibility with biofilm and low toxicity. Pharmaceutical liposome materials are usually composed of phospholipids and additives, in which phospholipids are the main components of the physical and biological properties of liposomes. The preparation method of amino polyethylene glycol derivative (nh2-peg-dspe) is as follows Then, the azido group was reduced to amino group by catalytic hydrogenation, and the amino polyethylene glycol derivative of distearoylphosphoroethanolamine, namely phospholipid polyethylene glycol amino group, was obtained.