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2025.01.30 23:33

[Focus Biomolecules 공식 대리점]-TJ-M2010-5 | MyD88 inhibitor,TJ-M2010-5 | MyD88 억제제(10-4919) CAS: 1357471-57-8

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TJ-M2010-5 | MyD88 inhibitor

CAS:
 1357471-57-8
Catalog Number:
 10-4919


TJ-M2010-5 (1357471-57-8) is an inhibitor of the toll-like receptor(TLR)/adaptor molecule myeloid differentiation factor 88 (MyD88) signaling pathway, crucial for inflammation and associated with the development of many inflammation-related cancers.1 It ameliorates ischemia-reperfusion injury in various organ models including brain2, liver3, and heart4. TJ-M2010-5 also suppressed proliferation, migration, and invasion in MCF-7 and MDA-MB-231 breast cancer cells.5 It prevented colitis-associated colorectal cancer by impairing myeloid-derived suppressor cells.6


TJ-M2010-5 (1357471-57-8)는 염증에 중요한 역할을 하며 많은 염증 관련 암의 발달과 관련된 톨유사 수용체(TLR)/적응분자 미엘로이드 분화 인자 88(MyD88) 신호 경로의 억제제입니다. 이는 뇌2, 간3, 심장4을 포함한 다양한 장기 모델에서 허혈-재관류 손상을 개선합니다. TJ-M2010-5는 또한 MCF-7 및 MDA-MB-231 유방암 세포에서 증식, 이동 및 침입을 억제했습니다.5 이는 골수유래 억제세포를 손상시켜 대장염 관련 대장암을 예방했습니다.6


CAS:1357471-57-8

Catalog Number:10-4919

Activity:MyD88 inhibitor

Chemical Names:3-(4-Benzylpiperazin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)propanamide

Molecular Weight:406.55

Molecular Formula:C23H26N4OS


Solubility:Soluble in DMSO (>25 mg/ml)

Physical Properties:White solid

Purity:>98% HPLC

NMR: (Conforms)


Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT


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References/Citations:

  1. Xie et al. (2016), Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer; J. Natl. Cancer Inst. 108 djv364
  2. Jiang et al. (2024), MyD88 Inhibition Attenuates Cerebral Ischemia-reperfusion Injury by Regulating the Inflammatory Response and Reducing Blood-brain Barrier Damage; Neuroscience 549 121
  3. Zou et al. (2023), The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice; Transplantation 107 392
  4. Yang et al. (2022), TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo; J. Cardiovasc. Transl. Res. 15 1366
  5. Liu et al. (2020), The MyD88 inhibitor TJ-M2010-5 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3ß and MyD88/NF-kB signalling pathways; Exp. Cell Res. 394 112157
  6. Wang et al. (2022), Blockade of Myd88 signaling by a novel MyD88 inhibitor prevents colitis-associated colorectal cancer development by impairing myeloid-derived suppressor cells; Invest. New Drugs 40 506

참고문헌/인용:

  • Xie et al. (2016), 대장염 관련 대장암 예방에서 새로운 합성 저해제 TJ-M2010-5를 통한 MyD88 호모다이머화 표적화; J. Natl. Cancer Inst. 108, djv364
  • Jiang et al. (2024), MyD88 저해제가 염증 반응을 조절하고 혈뇌장벽 손상을 감소시켜 뇌 허혈-재관류 손상을 완화함; Neuroscience 549, 121
  • Zou et al. (2023), 새로운 MyD88 저해제 TJ-M2010-5가 마우스 간 허혈-재관류 손상에서 파이롭토시스를 억제하여 보호 효과를 나타냄; Transplantation 107, 392
  • Yang et al. (2022), TJ-M2010-5가 생체 내에서 MyD88 호모다이머화를 억제하여 심장 이식에서 심각한 심근 허혈/재관류 손상을 완화함; J. Cardiovasc. Transl. Res. 15, 1366
  • Liu et al. (2020), MyD88 저해제 TJ-M2010-5가 MyD88/GSK-3ß 및 MyD88/NF-kB 신호 경로를 조절하여 유방암 세포의 증식, 이동 및 침윤을 억제함; Exp. Cell Res. 394, 112157
  • Wang et al. (2022), 새로운 MyD88 저해제를 통한 MyD88 신호 차단이 골수 유래 면역억제 세포 기능을 저해하여 대장염 관련 대장암 발생을 예방함; Invest. New Drugs 40, 506
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